Endocrine Abstracts

Diabetes mellitus is life threatening endocrine disorder with high morbidity and mortality, which is featured by persistent high blood glucose levels due to defect in the insulin secretion, insulin action or both. Extreme high blood glucose levels associated with diabetes leads to various organ dysfunction particularly nervous system, eye, cardiovascular system, and kidney. Kaempferol is a dietary bioflavonoid that is common in plant-derived foods and used in traditional medic...

Objective: This study was planned to examine the effect of galangin on hyperglycemia mediated oxidative stress in streptozotocin (STZ)-induced diabetic rats.Methods: Diabetes was induced by intraperitoneal administration of low dose of STZ (40 mg/kg body weight (BW)) into male albino Wistar rats. Galangin (8 mg/kg BW) or glibenclamide (600 μg/kg BW) was given orally daily once for 45 days to normal and STZ-induced diabetic rats.<p class="abstext...